Anguish, by August Friedrich Albrecht Schenck, c. 1878. National Gallery of Victoria, Melbourne.
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Miscellany
The first known “laboratory rat” was used in 1828 in an experiment about fasting. Guinea pigs have been put to scientific use since the 1780s, when Antoine-Laurent Lavoisier measured their heat production. The first recorded usage of guinea pig to liken a person or a thing to a test subject was in 1891, by George Bernard Shaw in his book The Quintessence of Ibsenism.
If you are a dog and your owner suggests that you wear a sweater, suggest that he wear a tail.
—Fran Lebowitz, 1981
