Overworked and suffering from chest and stomach conditions, Emperor Marcus Aurelius took a prescription from his physician, Galen, for opium. According to Galen, the emperor did not like that the drug made him drowsy, so he stopped taking it. Then he found himself unable to sleep, so he started taking it again.

Primo Levi wrote that at Auschwitz “a large amount of alcohol was put at the disposal of” members of the Special Squad, inmates of the concentration camp who were forced to work the crematoriums, “and that they were in a permanent state of complete debasement and prostration.” One such inmate said, “Doing this work, one either goes crazy the first day or gets accustomed to it.”