The first known “laboratory rat” was used in 1828 in an experiment about fasting. Guinea pigs have been put to scientific use since the 1780s, when Antoine-Laurent Lavoisier measured their heat production. The first recorded usage of guinea pig to liken a person or a thing to a test subject was in 1891, by George Bernard Shaw in his book The Quintessence of Ibsenism.

“A seaman in the coach told the story of an old sperm whale, which he called a white whale, which was known for many years by the whalemen as Old Tom, and who rushed upon the boats which attacked him, and crushed the boats to small chips in his jaws, the men generally escaping by jumping overboard and being picked up,” recorded Ralph Waldo Emerson in his journal on February 19, 1834, adding that the whale “was finally taken somewhere off Payta Head by the Winslow or the Essex.” It was the wreck of the Essex in 1820 from which Herman Melville drew inspiration for Moby Dick.