On November 22, 1963, Aldous Huxley, bedridden and dying, requested on a writing tablet that his wife Laura give him a 100 microgram dose of LSD. As she went to get the drug from the medicine cabinet, Laura was perplexed to see the doctor and nurses watching TV. She gave him a second dose a few hours later, and by 5:20 p.m. he had died. Laura later learned that the TV had been showing coverage of the assassination of John F. Kennedy, who had been pronounced dead at 1:00 p.m. that day.

Sent to suppress elements of Nathaniel Bacon’s Rebellion in 1676, British soldiers made a soup seasoned with Datura stramonium, a hallucinogen, “the effect of which,” as an eighteenth-century historian put it, “was a very pleasant comedy; for they turned natural fools upon it for several days; one would blow up a feather in the air, another would dart straws at it with much fury, and another, stark naked, was sitting up in a corner, like a monkey, grinning and making mows at them.” D. stramonium became known as jimson weed, named after Jamestown, Virginia, where the soldiers had been sent.

“I have absolutely no pleasure in the stimulants in which I sometimes so madly indulge. It has not been in the pursuit of pleasure that I have periled life and reputation and reason. It has been in the desperate attempt to escape from torturing memories,” wrote Edgar Allan Poe in a letter in the last year of his life.

The questions “Have you ever used Derbisol?” and “How often?” sometimes appear along with questions about alcohol, cocaine, and marijuana use on youth-risk surveys for students. Derbisol is a fictitious drug devised to test the reliability of the responder. In one survey, 163 of 894 students said that they had tried Derbisol—or 18.2 percent.

Isolated from opium by the German chemist F. W. A. Sertürner around 1804, morphine (named after Morpheus, the Greek god of sleep and dreams) was used to treat opium addicts. Invented by Bayer Pharmaceuticals in 1898, heroin (derived from the Greek word for hero) was used to treat morphine addicts.

Overworked and suffering from chest and stomach conditions, Emperor Marcus Aurelius took a prescription from his physician, Galen, for opium. According to Galen, the emperor did not like that the drug made him drowsy, so he stopped taking it. Then he found himself unable to sleep, so he started taking it again.